Allergic rhinitis (hay fever) in children is a common condition, present more often during certain times of the year, when allergens such as pollen, mould, and dust are in excess. Immunologically it is  characterized by a Th2 polarized immune response and Ig-E antibody production. 

1 in 5 people in the UK experience symptoms of allergic rhinitis which is characterised by the inflammation of the nasal mucous membrane and can also involve the eyes, ears, sinuses, and throat. Commonly linked to conjunctivitis and asthma, allergic rhinitis is a long-standing condition frequently undetected in primary care settings. 

The classic symptoms of the disorder are frequently confused with other respiratory or rhinitis-based symptoms, such as congestion, rhinorrhoea, sneezing, and itching. Thorough physical examinations and allergen testing are recommended for the detection of the condition. Unfortunately, the mainstay treatment of second-generation antihistamines and intranasal corticosteroids are frequently inefficient as a long-term solution. 

Increasing Prevalence of Allergic Rhinitis

Research indicates that up to 40% of the population may already be influenced by rhinitis in some way, characterised by inflammation of the nasal mucosa. Studies also indicate that the prevalence of the disorder is increasing and may be responsible for numerous significant long-term impairments. 

One study into children with allergic rhinitis demonstrated significant learning impairment influenced by the acute symptoms of the condition. Symptoms, including inflammation of the eyes, sinuses, nose, pharynx, larynx, and various areas of the respiratory system, impact concentration. Systematic reviews indicate that frequent exposure to these conditions can be detrimental to sleep, quality of life, and performance in work or school. 

Unfortunately, concentration and quality of life impairments appear to be exacerbated by the use of traditional antihistamine-based treatments. One study found a negative impact on clerical accounting, visual attention, auditory and visual memory, and mathematical skills when taking antihistamine substances. 

Previously, allergic rhinitis was considered a disorder localized specifically to the nasal passages, but further study indicates it may be a component of a systematic airway condition, involving the entire respiratory system. Evidence further shows that inflammation in the upper airway caused by allergic rhinitis may also lead to inflammatory processes in the lower airways, supporting the connection between rhinitis and asthma. 

The Importance of Immunomodulation

Where traditional treatments of allergic rhinitis may have lasting side-effects, natural solutions in the form of medicinal mushrooms could offer a risk-free alternative. Allergic responses stem from hypersensitivity to substances that would otherwise pose no danger to an individual in the environment. 

Common allergic disorders, like allergic rhinitis in children, are influenced fundamentally by the immune system and the body’s production of histamine. Mycomedicine, or the use of medicinal mushrooms, provides timely support for seasonal and year-round rhinitis issues. The Royal Sun Agaricus (Agaricus Blazei Murill) offers proven antihistaminic and immunomodulatory effects as a nutraceutical for allergy treatment. 

The Agaricus blazei mushroom stimulates weakened immune system and brings balance to the Th1 and Th2 responses in the body, which is predominantly Th2 in an allergic rhinitis.  Therefore, its supplementation is useful as an immunomodulator that acts as a natural anti-histaminic remedy. Further biocomponents in the mushroom reduce the release of histamine release in mast cells, lowering allergic response. A clinical study in 2019 showed a reduction of general allergy, asthmatic symptoms and even permitted a reduction in the use of the medication when supplemented with a concentrated mushroom extract based on Agaricus blazei. 

Reishi mushroom (Ganoderma lucidum) further reduces inflammation and reduces the release of histamine release by mast cells. Reishi is also an adaptogen, capable of adapting to various sources of stress by adjusting altered bodily states. Reishi is further suitable for reducing feelings of stress, which can further exacerbate allergic conditions. 

Addressing Inflammation and Microbiota balance

Inflammation is a significant side effect and symptom of allergic rhinitis in children. When exposed to allergens, the body releases substances like histamine which influence swelling. There are various natural approaches to treating inflammation, like eating more foods with anti-inflammatory qualities such as flaxseed and fish. Natural extracts like Reishi mushroom can modulate the immune system response and reduce inflammation simultaneously. 

The high content of anti-inflammatory bioactive compounds in Reishi, triterpenes, gives Ganoderma lucidum an anti-inflammatory action comparable to hydrocortisone without the side effects.  Triterpens, or commonly known as terpens, work alongside other beneficial substances to address the underlying issues of allergic rhinitis in children. 

The consumption of vitamin C alongside mushroom solutions for allergic rhinitis will increase the absorption of some of the bioactive compounds in the substance, such as beta-glucans. Supplemental substances that combine medicinal mushrooms with vitamin C can therefore enhance the natural response of the protocol. Including prebiotics like medicinal mushrooms within the treatment strategy further promotes the growth of healthy bacteria in the microbiota. 

The development of beneficial bacteria can balance the intestinal microbiota which has a long-term impact on children’s health, and their ability to identify viruses and bacteria and differentiate between dangerous and safe entities more effectively. 

Medicinal mushrooms, which are natural prebiotics, together with vitamin C could deliver a long-term solution for allergic rhinitis in children that has none of the dangerous side-effects of traditional treatment routes. These solutions can further be combined with other natural products which offer supportive flavonoids (antioxidants) for helping with inflammation in this condition. 

When dealing with natural products such as medicinal mushrooms, however, it is crucial to ensure the synergised blend of products used in the treatment are concentrated in high quality nutraceuticals, without chemical additives, being as natural as possible and which have been standardized in their active compounds. Preference for organic extracts and quality seals like gluten free or vegan will always indicate that the product has been made with maximum care. 

In the UK, 44% of adults suffer from an allergy. Around half of sufferers have multiple allergies, which accounts for approximately 10 million people [1]. One of the most common is hay fever, clinically known as allergic rhinitis. Characterised by cold-like symptoms, such as a runny nose, itchy eyes, congestion, sneezing and sinus pressure, effective hay fever treatment and prevention is still struggling to cope for clinicians.

Before going further, it is useful to outline the nature of allergies. Essentially, an allergy is an unnatural immune response. The reaction occurs when the presence of foreign peptides in the mucous membranes triggers a Th2 dominant pro-inflammatory state. In the case of hay fever, these foreign peptides could be pollen, dust mites, or particles of skin or saliva shed by pets.

In either context, hay fever is primarily an immunological issue. Therefore, hay fever treatment – and ultimately prevention – should be addressed via immunomodulation. This is what makes medicinal mushroom nutraceuticals such an interesting proposition, which we will explore here.

The Benefits of Agaricus blazei Murill for Hay Fever Sufferers

Agaricus blazei Murill (AbM), or Royal Sun Agaricus, is an edible, medicinal mushroom originating in Brazil. Traditionally, it was used against a range of diseases, including cancer and hepatitis. However, AbM researchers have recently discovered its powerful immunomodulatory properties, which has led to increasing interest [2].

Studies have shown that AbM brings the Th1 and Th2 response into balance, which in regard to hay fever treatment, acts as an anti-histaminic remedy. Achieving this equilibrium due to the specific bio components that inhibit histamine release by mast cells and reduce IgE specific allergy antibodies. The health benefits that arise are both in preventative and therapeutic applications [3]. 

For instance, a clinical study in 2019 showed that, alongside common medical treatment, AbM supplementation yielded a significant reduction of general allergy and asthma symptoms in birch pollen allergic participants [4].

Anti-allergic activities of other Medicinal Mushrooms 

Ganoderma lucidum, or Reishi mushroom, also has been shown to have immune-modulating and immune-potentiating capabilities [5]. Reishi extract contains triterpenes, which generate antioxidant, antihistamine and significant anti-inflammatory activity. In fact, it’s suggested that Ganoderma lucidum has an anti-inflammatory action comparable to hydrocortisone without the negative side effects.

Moreover, in regard to a holistic approach to hay fever treatment, medicinal mushrooms have many benefits. For example, the polysaccharide content of both mushroom species mentioned precipitates a substantial prebiotic effect, which is beneficial for immune function [6].

A Holistic Approach to Hay Fever Treatment   

A holistic, well-being oriented approach to managing hay fever addresses the issue at its root. By supplementing common medical treatments with lifestyle changes, clinicians can seek to prevent allergies as well as treat the symptoms. This could include changes in diet, such as the introduction of therapeutic whole foods like nettles, cleavers, and elderflowers. Equally, onions and apples contain quercetin, which has antioxidant and anti-inflammatory effects. 

However, research is increasingly showing that mushroom nutraceuticals could be one of the most effective lifestyle changes for hay fever treatment. By modulating the immune response and histamine levels, we can address both long-term functional support and current symptoms. Ideally, healthcare professionals should recommend high quality concentrated extracts, preferably organic and standardized in its bioactive compounds. Regarding dosage, it is advisable to adjust it depending on the patient’s evaluation and symptomatology.

References

1. https://www.allergyuk.org/hayfever/allergies-in-the-uk
2. Hetland G, Johnson E, Lyberg T, Bernardshaw S, Tryggestad AM, Grinde B. Effects of the medicinal mushroom Agaricus blazei Murill on immunity, infection and cancer. Scand J Immunol. 2008 Oct;68(4):363-70.
3. Ellertsen LK, Hetland G. An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy. Clin Mol Allergy. 2009;7:6. Published 2009 May 5.
4. Mahmood F, Hetland G, Nentwich I, Mirlashari MR, Ghiasvand R, Nissen-Meyer LSH. Agaricus blazei-Based Mushroom Extract Supplementation to Birch Allergic Blood Donors: A Randomized Clinical Trial. Nutrients. 2019 Oct 2;11(10):2339.
5. Bhardwaj N, Katyal P, Sharma AK. Suppression of inflammatory and allergic responses by pharmacologically potent fungus Ganoderma lucidum. Recent Pat Inflamm Allergy Drug Discov. 2014;8(2):104-17.
6. Wu, H. J., & Wu, E. (2012). The role of gut microbiota in immune homeostasis and autoimmunity. Gut microbes, 3(1), 4–14.

Immune support supplement works as a complement to our immune system. Immunity is a complex system that comprises of several key processes such as activation of macrophages, antigen presentation, and response from lymphocytes. Our body has to create just enough amount of immunity to tackle the pathogens. Too few or too many of them lead to uncontrolled illness and damage to the body systems.

Therefore, immunomodulation works by either boosting or suppressing the immune response towards infections and undesirable conditions. Immunomodulatory agents are often used for treating infections, preventing immunodeficiency, and tumors. Immunomodulators can regulate the immune system to combat infections effectively. In the gut, they stabilize the composition of the gut microbiota by inhibiting harmful microbiota and stimulating health-promoting gut microbiota. 

In an infection, immunomodulators don’t work directly by targeting the pathogens; instead, they modulate the innate and adaptive immune system to combat the condition effectively. This will avoid the development of microbial resistance and can be helpful to immunocompromised patients who cannot take antimicrobial and antiviral drugs.

They are especially critical in oncology cases as they can enhance immunological response to tumor cells. Very recently, immunomodulators are also included in Covid-19 therapy to attenuate the cytokine storm that leads to severe acute respiratory distress syndrome (ARDS).

Mycomedicine in Immune Support Supplement

In the effort of developing natural sources as immunomodulatory agents, medicinal mushrooms are found to be suitable reservoirs of immune-enhancing compounds, experts say. These components have been extensively studied for their ability to modulate the immune system:

1. β-glucans
2. Triterpenoids
3. Lectins

β-glucans work by activating various immune system components such as macrophages, neutrophils, NK cells, and lymphocytes. Combined with oncological treatments, β-glucans can enhance the immune response by binding to pattern recognition receptors that can improve resistance to infections and promote antitumor activity.

Other than having immunomodulatory effects, β-glucans are also known as prebiotics.  β-glucans can induce the growth of Prevotella and Roseburia, the gut microbiota that play critical roles in maintaining health equilibrium. Gut microbiota can boost the immune system, prevent the growth of harmful bacteria, and protect the epithelial integrity. A report shows that unbalanced gut microbiota is often linked with various diseases such as gastrointestinal disorders, obesity, cardiovascular disorders, allergy, and neural diseases. Other studies are highlighting the importance of microbiota modulation in cancer. Even a recent Nature publication states that “gut microbiota modulation, with the aim to reverse established microbial dysbiosis, is a novel strategy for prevention and treatment of colorectal cancer. Different strategies including probiotics, prebiotics, postbiotics, antibiotics, and fecal microbiota transplantation (FMT) have been employed.”

Triterpenoids and lectins have both antiviral and anti-inflammatory activity. These compounds showed a potent inhibitory activity against numerous human patho-genic viruses such as HIV, herpes simplex virus type 1 and 2 (HSV-1 and HSV-2), hepatitis C virus (HCV) and influenza virus. Lectins can also stop the replication of the SARS-CoV virus that causes severe lower respiratory tract infections, as in the Covid-19 disease. Triterpenoids themselves have anti-inflammatory effects by suppressing NF-κB release, blocking DR4 and DR5 pathways, and inhibiting active caspases which all contribute to inflammation process.

Numerous Medicinal Mushroom Species Have Immunomodulatory Effects

Medicinal mushrooms such as Ganoderma lucidum (Reishi), Lentinula edodes (Shiitake), and Grifola frondosa (Maitake), and Inonotus obliquus (Chaga) are well known to exert immunomodulatory effects. Their polysaccharides and protein contents stimulate the activity of the immune components such as B and T lymphocytes, dendritic cells, macrophages, cytokines, and NK cells.

By enabling the immune system, these mushrooms are also able to inhibit tumor growth. Reishi has been proven significant as an adjunctive treatment for lung, leukemia, and prostate tumor. In a 2014 article, Maitake demonstrated its antitumor ability for breast and colon cancer, and Chaga is well-known to be a promising therapeutic agent for hepatocellular carcinoma.

Conclusion

There’s no denying that compounds derived from natural products such as mushrooms are proven to be safe, affordable, and accessible. Medicinal mushrooms are a significant source of nutrients that can be found in an immune support supplement. Immunomodulation is one of the best known health benefits that medicinal mushrooms have to offer. With its abundant bioactive compounds and various health-promoting actions, myco-medicine can help our immune system to combat infections, tumors, and autoimmune diseases. 

 

Mycotherapy is an integrative healthcare practice that uses plants from the fungus family and their derivatives – or, in simple terms, medicinal mushrooms. This term was coined by researchers at biotech Hifas da Terra in 2006, and since, it has become the recognised term for mushroom therapies globally. These fungi and their fractions have various preventative and integrative therapeutic applications, providing support for various pathologies.

Medicinal mushrooms have been prized for their benefits by diverse cultures for centuries. For instance, Ganoderma has been used as a tonic and treatment for various pathologies, including chronic hepatopathy, hypertension, neurasthenia, anxiety, insomnia, bronchitis, gastric ulcer, diabetes, and cancer in China, Japan, Korea, and other Asian countries for over 2,000 years [1]. Meanwhile, Ayurvedic practices similarly revere mushrooms for their holistic nutrition and health benefits.

Today, an increasing amount of scientific evidence is emerging about the efficacy of these traditional medicines which are, in fact, natural nutrients. These studies are demonstrating that mushrooms are indeed potent producers of bioactive substances that can support health and well-being. A single species of medicinal fungus can contain hundreds of bioactive compounds, with hypolipidemic, immunomodulatory and even antitumor activities. 

Certainly, mycotherapy presents exciting prospects for a move towards patient-centred, preventative healthcare. Here, we give an overview of the evidence and discuss why mycotherapy is one of the most innovative tools in integrative therapy today.

Integrative and Innovative Protocols are Changing Healthcare   

Until relatively recently, many healthcare professionals in the Western world subscribed to a reductive view of the body. That is, medicine focussed on disease in its constituent parts, as opposed to the health of the whole. Now, healthcare practitioners are increasingly recognising the benefits of a holistic approach to health, which focus on preventative care and well-being as much as treatment. Taking inspiration from ancient disciplines such as Traditional and Ayurveda, this shift signals a more pluralistic, patient-centred approach to care.

Equally, these disciplines can help to alleviate the side effects triggered by conventional medical treatments. These approaches – captured under the term integrative medicine – neither reject conventional medicine nor adopt alternative methods uncritically. Instead, it acknowledges that medicine should always be open to new research, no matter its biological, cultural, or philosophical basis. This opens healthcare practice to new paradigms of wellness, improving patients’ quality of life.

Broadly speaking, integrative therapy is divided into two main disciplines: mind-body therapies and natural products. Mind-body therapies include manipulative techniques like massage and chiropractors and spiritual practices like yoga or tai chi. Meanwhile, natural products are dietary supplements and nutritional programmes. Mycotherapy falls into this second category to promote overall health and well-being. 

In contrast to traditional phytotherapy or vitamin-mineral supplementation, mycotherapy offers naturally-occurring phytochemicals and vitamins and minerals from a sole source. This is especially beneficial for patients undergoing intensive medical treatments such as chemo- or radiotherapy, who need non-toxic, inert solutions for managing secondarisms.

Emerging Evidence for the Efficacy of Mycotherapy

Now, an increasing amount of research is emerging to support the case for Mycotherapy. This is particularly relevant to patients living with chronic conditions. For example, scientists at the Beijing Normal and Hong Kong Baptist Universities conducted a large scale study on the effect of Ganoderma, Chaga, Coriolus and Maitake mushrooms on patients with chronic bowel complaints. The results were remarkable: there was a marked increase in microbial diversity in the gut and a localised anti-inflammatory response [2].

Furthermore, these benefits extend far beyond the digestive tract. For example, a recent study presented compelling evidence that Mycotherapy has significant benefits for patients living with chronic fatigue. In a study related to athletic performance, Cordyceps and Reishi mushrooms were shown to protect athletes from nonfunctional overreaching (NFO) and overtraining syndrome (OTS). This was measured via salivary cortisol and testosterone levels in cyclists [3].

However, perhaps the most compelling evidence for the holistic health benefits of mycotherapy is its immunomodulatory action provided by medicinal mushrooms and their bioactive immunoregulatory products [4]. Unlike other immunological strategies, immunomodulation consists of providing “soldiers and generals” to our immune system so that it can organize to fight against viruses or cancer cells. In this sense, nutritional supplements based on medicinal mushrooms are different from drugs because they help the body give an orderly response. In addition, the bioactive potential of these compounds has been demonstrated in some remarkable contexts, including oncology.

One such example is a phase 1 clinical trial conducted on women with breast cancer. In the study, researchers applied a fraction of Trametes versicolor, or the Turkey Tail mushroom. After, researchers recorded increased lymphocyte counts, increased natural killer cell functional activity and dose-related increases in CD8(+) T cells and CD19(+) B cells, suggesting this mycotherapy protocol could have significant benefits for immunocompromised breast cancer patients [5].

However, perhaps most relevant to our current moment is research on the immunomodulatory action of mycotherapy in COVID-19. In an ongoing study conducted by Hifas da Terra at a Madrid care home on residents with an average age of 87.2 years diagnosed with COVID-19, fatality rates plummeted from 24.1% to 1.4% after receiving a supplementation based on mushroom nutraceuticals. Equally, more than 88% of the patients who followed the prescribed protocol did not manifest complications associated with COVID-19 and none required admission to the ICU (hospital admission dropped from 27% to 12.3%). These are the first results of a study which is now being extended to other nursing care homes to confirm the efficacy of mycotherapy in a wider population [6].

The Overall Mind and Body Benefits

These immunological properties of medicinal mushrooms mean that Mycotherapy isn’t only useful for supporting treatment – it also has substantial benefits for overall health. For instance, varieties such as Royal Sun Agaricus are rich in proteoglycans, a type of protein important for immune health. Along with beta-glucans and lipids, including linoleic acid and phospholipids, this variety has anti-allergic and immunostimulatory properties [7].

A further example is the Ganoderma or Reishi mushroom. Referred to as ‘the mushroom of immortality’ in Eastern medicinal practices, certain unique compounds of Reishi have impressive anti-inflammatory properties. Moreover, they are thought to be one of the most powerful natural antioxidants in existence, acting on the primary cause of cellular oxidation and ageing [8]. Equally, they are known to have significant antidepressant effects, with various studies demonstrating mood-lifting action [9].

The mental and emotional health benefits of mycotherapy have also been demonstrated with other species. For instance, Hericium erinaceus, a well known edible mushroom, has various biological activities. In a recent study on female patients with depression and sleep disorders, an extract of H. erinaceus was shown to stimulate nerve growth factor (NGF) synthesis, which affects brain function and the nervous system. Results showed that H. erinaceus intake had the possibility to reduce depression and anxiety via its NGF-enhancing action [10].

Selecting Quality Mycotherapy Products

Certainly, there is a wealth of compelling evidence emerging to support the use of mycotherapy in mainstream medicine. However, it is essential that healthcare professionals select quality products. Practitioners should choose ecological, safe and effective supplements developed by experts that are invested in research. As mycotherapy is primarily evidence-based, professionals should trust biotechs that are constantly innovating. 

Biotechs should select strains for their quality, which are further optimised via ecological, organic farming methods. The formulas should contain all of their natural active compounds in their purest form, concentrated and unchanged. Equally, professionals should look for brands with quality assurance standards, where production is uniform, controlled, and regulated by an external organisation such as Good Manufacturing Process (GMP) for pharmaceuticals.

Third party verification is critical across a number of factors; this is especially the case regarding supplements interaction with other medications. Healthcare professionals should preferably look for biotechnology centers that collaborate with external laboratories to verify their safety. Equally, patented formulas and endorsements from regulatory bodies are a hallmark of quality.

Perhaps the most important thing to look for in a mycotherapy product is the manufacturer’s commitment to R&D. As new developments emerge, products should be continually tested and optimised via controlled, clinical trials – this is, after all, the best practice for any medicinal substance. Before selecting a mycotherapy product, explore the biotech’s portfolio of research projects – this will be a good indicator as to their investment in innovation.  

The Future of Mycotherapy

Evidence about the benefits of Mycotherapy is proliferating. Now, there is growing acceptance in the medical community that integrative protocols like mycotherapy have substantial benefits. This is reflected in the growing availability of training in medical schools; according to a survey conducted in 2013, there were 13 American medical schools offering fellowships in integrative medicine.

This is because the evidence is undoubtedly compelling. When it comes to managing the effects of chronic conditions and secondarisms, research has shown that mycotherapy protocols can improve patients’ quality of life. Moreover, patients appreciate this renewed attention to overall well-being; instead of being treated merely as a symptom, integrative therapies position the body as a whole system. In this context, patients feel their unique needs are addressed.

As interest in the field grows, researchers are continuing to innovate. New discoveries are emerging all the time, with far-reaching R&D projects covering everything from anti-ageing ingredients to antiproliferative action on tumours. Looking to the future, mycotherapy could form the basis of innovative bio-pharmaceutical treatments – signalling a natural, integrative, and pluralistic future for modern medicine and complementary therapy. 

References

1. Sanodiya B.S., Thakur G.S., Baghel R.K., Prasad G.B., Bisen P.S. Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol. 2009;10:717–742.
2. Jayachandran, Muthukumaran & Xiao, Jianbo & Xu, Baojun. (2017). A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota. International Journal of Molecular Sciences. 
3. Paola Rossi, Daniela Buonocore, Elisa Altobelli, Federico Brandalise, Valentina Cesaroni, Davide Iozzi, Elena Savino, Fulvio Marzatico, “Improving Training Condition Assessment in Endurance Cyclists: Effects of Ganoderma lucidum and Ophiocordyceps sinensis Dietary Supplementation”, Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 979613, 11 pages, 2014.
4. Zhao S, Gao Q, Rong C, et al. Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products. J Fungi (Basel). 2020;6(4):269. Published 2020 Nov 8.
5. Torkelson CJ, Sweet E, Martzen MR, Sasagawa M, Wenner CA, Gay J, Putiri A, Standish LJ. Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer. ISRN Oncol. 2012;2012:251632.
6. https://hifasdaterra.co.uk/wp-content/uploads/2020/10/EN-NP-trial-nursing-homes-residents.pdf
7. Wang, Hang & Fu, Zhiming & Han, Chunchao. (2013). The Medicinal Values of Culinary-Medicinal Royal Sun Mushroom (Agaricus blazei Murrill). Evidence-based complementary and alternative medicine : eCAM. 2013. 842619. 10.1155/2013/842619.
8. Mohsin M, Negi P, Ahmed Z. Determination of the antioxidant activity and polyphenol contents of wild Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (W.Curt. Fr.) P. Karst. (higher Basidiomycetes) from central Himalayan hills of India. Int J Med Mushrooms. 2011;13(6):535-44.
9. Matsuzaki H et al., (2013) Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats. BMC Complementary and Alternative Medicine 13, 370.
10. Anderson KO, Getto CJ, Mendoza TR, Palmer SN, Wang XS, Reyes-Gibby CC, Cleeland CS. Fatigue and sleep disturbance in patients with cancer, patients with clinical depression, and community-dwelling adults. J Pain Symptom Manage. 2003 Apr;25(4):307-18.

 

Skin keratinisation disorders are known to form layers of crusted epithelium, which are not only problems of esthetic and comfort, but also of cancer potential. This group of disorders with abnormal keratinisation are known as porokeratosis. The most common form of porokeratosis is the disseminated superficial actinic porokeratosis (DSAP), which afflicts patients through accelerated keratinisation of the skin, thickening it further, especially in the third to fourth decade of life. This specific variant of actinic keratosis warrants an efficient medical attention to prevent the development of cancer. According to a study, the overall management of this condition has not been maximized in varying aspects, including access to field treatments, therapeutic approach, and referral rates from primary health care physicians.

Besides an inadequate cost-benefit treatment plan, actinic porokeratosis is often misdiagnosed due to the similarity of its clinical picture with other dermatologic manifestations. As sun exposure is contributory to the prominence of the skin lesions, it is often mistaken as other skin conditions. Misdiagnosis brings about erroneous treatment plans that can aggravate the current condition of the patient.

Pathophysiology. How does it develop?

In general, DSAP is a genetic disease inherited through autosomal dominant fashion, which means that if just one parent passes on the defective gene, the child will be affected. While the evolution of the lesions are unclear, some etiology are suspected including exposure to radiation, immune-mediation, and even infection. As the sites of affectation have been observed in areas with sun exposure, it is suspected that solar radiation significantly contributes to the incidence of DSAP, growing multiple reddish or colored annular hyperkeratotic lesions, presenting as macules, papules, and plaques surrounded by edges of increased keratinisation with an atrophic centre. This has been widely observed in Australians who have had an increase in sun exposure throughout their lifetime.

Pharmacological and integrative treatment: Why do we need help from mycotherapy?

The current standard practice has no definitive evidence-based treatment for any form of actinic porokeratosis. This dermatologic condition has been studied in previous cases which used retinoid creams, 5-fluoriouracil, iquimoid cream, ingenol mebutate gel and other topical treatments as the primary management. Here is where mycotherapy can help, by addressing solutions for this unsolved problem.

As incidences are directed to general practitioners, the DSAP has been one of the subjects of misdiagnosis as clinical presentation is uncanny, with practitioners ending up with a final diagnosis of rashes or other skin lesions. Healthcare professionals should be educated on the incidence and prevalence of porokeratosis, especially in areas with higher cases. If treatment of these type of lesions is not correctly approached, they may progress to skin cancer, whether squamous cell carcinoma, or basal cell carcinoma, and with a smaller incidence, melanoma as well.

In this context, mycological approaches are being studied in order to improve the standard therapy and offer complementary tools against hyperkeratosis and malignant potential of DSAP.

Chaga mushrooms.

 Inonotus obliquus is discovered to have betulinic acid initially isolated back in 1788 [6]. Upon extraction from the outer bark of white birch trees,  this has been found to induce programmed cell death in pre-cancerous cells, such as the ones that can be present in actinic porokeratosis. In previous studies, betulin from Chaga mushrooms has resulted in significant tumor regression, with minimal toxicity to healthy cells.

Reishi mushrooms

Ganoderma lucidum has been used for decades due to its multiple benefits and its high content in terpenoids. Besides, polysacharides and other bioactive molecules, more than 200 triterpenes have been identified from the fruiting bodies, spores, and mycelia of this mushroom. Studies show that these terpenoids exhibit anti-cancer, antioxidant and antiinflammatory properties, which can be very useful in dermatological conditions like actinic porokeratosis [7].

Turkey tail

Along with Reishi, Coriolus versicolor has been noted to have significant amounts of terpenoids that are active in reprogramming the capacity of the cell to undergo apoptosis. In fact, a Turkey tail extract was found to inhibit the mitotic potential of cells that underwent mutation due to radiation exposure, and also by reduction of the tumor size.

Along with these mushrooms, other natural remedies, with more limited evidence of effectiveness, have been used to improve the standard treatment of actinic keratosis including apple cider vinegar, virgin coconut oil, tea tree oil, and even green tea.

Conclusion

Actinic keratosis has been highly prevalent through the years and has been an important basis of skin cancer because of its neoplastic potential. This condition requires medical and integrative management plans that can significantly reduce the development of cancer and other complications and should have been prioritized in the current setting. This is where mycotherapy should be looked into, further studying their bioactive substances to deal with the hyperkeratosis and to prevent the progression of cancer.

In addition, patient education in complementary therapies as adjuvants and in prevention should be also addressed.

With sports injuries like sprains, it’s vital to restore proper function as soon as possible. This is particularly the case with ankle sprains, where chronic instability can cause the ankle to give way while walking, running, or standing. In addition to the usual range of motion and strength training, rehabilitation should include exercises that restore the body’s kinesthetic awareness, or sense of its position in space. Medically termed ‘proprioception exercises’, these movements help re-familiarise the body with the sensation of joint movement.

Proprioception is a largely unconscious ability that allows us to, for example, walk down the stairs without looking at our feet. Without proper rehabilitation, chronic ankle instability can lead to repeated injury, arthritis, or tendon issues. Meanwhile, ageing takes its toll on our proprioception, so maintaining these functions are essential to the patient’s well-being long term.

Why Proprioception Exercises Aren’t Only for Sports Injuries

Proprioception exercises such as balance training have been shown to prevent ankle re-injury in athletes and reduce the risk of long term ligament problems [1]. However, they have benefits beyond sports medicine; they have also been shown to help reduce the risk of falls in older people and women with low bone mass and to improve postural stability after a stroke [2].

There is also research underway to ascertain it’s benefits for overall mobility and preventing falls and injury for people with neurological or orthopaedic conditions. For example, other recent studies that suggest that proprioception exercises could be a beneficial integrative therapy for patients with Parkinson’s disease. [3]

More research is needed to identify which proprioception exercises are most beneficial according to each condition. However, as part of a regular exercise regime of at least 30 minutes of moderate activity every day, proprioception exercises have clear benefits. This is particularly the case for patients with issues with balance, whether it be a chronic condition or injury.

Incorporating Balance Training into Daily Life

What’s good about proprioception exercises is that you don’t need a lot of equipment to perform them – therefore, it’s easy to get patients to incorporate these exercises into their daily routine. These exercises will also help build strength, which will further improve stability and reduce the risk of falls.

Below are some ideas for proprioception exercises that patients can do with the supervision of a physiotherapist or integrative healthcare professional. With these simple moves, the patient can complement their treatment and be on their way to better balance in no time.

• Stand on one leg when waiting in queues.
• Use a ‘wobble board’ when standing at work or talking on the phone.
• Play catch while standing on one leg and then the other.
• Sit down and stand up from a chair without using your arms.
• Walk as if you were on a tightrope.
• Take up tai chi or a dance class. Choreography is great for spatial and bodily awareness, so this has many physical benefits as well as being an enjoyable hobby.

Enhancing Therapies with Proprioception Exercises

Proprioception exercises such as balance training are an integral part of a comprehensive approach to injury recovery. With its adaptability and ease of practice, it’s becoming increasingly popular among sports medics and physiotherapists. Alongside strength and flexibility training, proprioception exercises can help ensure the patient recovers the full scope of movement in the affected joints and ligaments. With an increasing amount of research to suggest that these exercises can also help those with chronic conditions, the incorporation of proprioception exercises is becoming more widespread among integrative therapists.

References

1. Barrack R., Skinner H., Buckley S. (1989). Proprioception in the anterior cruciate deficient knee. Am. J. Sports Med. 17, 1–7.
2. Meyer S., Karttunen A. H., Thijs V., Feys H., Verheyden G. (2014). How do somatosensory deficits in the arm and hand relate to upper limb impairment, activity, and participation problems after stroke? A Systematic Review. Phys. Ther. 94, 1220–1231.
3. Konczak J., Sciutti A., Avanzino L., Squeri V., Gori M., Masia L., et al. . (2012). Parkinson’s disease accelerates age-related decline in haptic perception by altering somatosensory integration. Brain 135(Pt 11), 3371–3379.

The organic nutrition industry is growing at an incredible rate, ready to reach a value of $320 billion by 2025. Countless companies are now investing more money and time into the potential of natural and organic food, but consumers are still questioning the true value of this solution.

In the last few years, the growth of the organic food sector has highlighted a growing trend for customers to focus more carefully on the ingredients they put into their bodies. During the COVID-19 pandemic of 2020, the sales of organic food and drink grew even further, driven by an increased focus on wellness.

But what are the scientific health benefits of going organic? Can the research prove the value of organic eating as part of a full wellness strategy?

The ingredients of organic nutrition

For clinical professionals interested in confirming the benefits of organic nutrition, the research begins with the ingredients within this food. Organic fruits and vegetables are grown without the assistance of synthetic pesticides and fertilizers. While these substances are generally deemed safe in conventional farming quantities, repeated exposure could be dangerous.

Common pesticides have been linked with developmental delays in humans, as well as reduced sperm quality in men, and even higher chances of mental conditions like ADHD. Organically-grown crops, on the other hand, are 48% less likely to test positive for dangerous substances like cadmium – a heavy metal that can accumulate in the kidneys and liver.

Organic nutrition can potentially replace dangerous substances with more nutritional benefits. Organic products in the milk and food landscape have 50% more omega 3 fatty acids. Switching to organic products could raise the intake of omega 3 in a standard consumer, without the risk of increased calories.

Replacing hormones with antioxidants

Further scientific study into organic nutrition finds that conventional livestock are often fed antibiotics to prevent against illness. Some livestock may also be injected with growth hormones that allow them to gain weight faster or increase production of milk. Traces of these substances can make their way into consumers, leading to a higher risk of antibiotic resistance, and problems with chronic illness.

Fortunately, eating organic nutrition could be the key to improving consumer diets. One study found that organic onions had a 20% higher content of antioxidants than conventional counterparts. Although experts are still exploring the full benefits of organic foods for nutrition purposes, the existing results are positive.

Another benefit worth considering is that today’s consumers don’t necessarily need to add extra foods to their diet to unlock the benefits of the right nutrition. Some of the biggest benefits of organic substances like medicinal mushrooms can be implemented in the form of regular supplementation. Most mushrooms have huge benefits when it comes to things like Vitamin D intake, but there are also mushrooms like Reishi, which can reduce the risk of inflammation in the body when taken as a supplement.

Clinical professionals recommending a diet of more organic substances could offer their clients the perfect combination of nutritional foods and supplemental solutions. This could be particularly useful for people who have dietary restrictions or preferences to consider.

Are organic foods essential to good health?

The benefits of organic nutrition are evident in the increasingly positive results of various studies into diet and consumer health. However, not everyone will be able to switch to a completely organic diet overnight. Today’s clinicians need to be aware that organic foods are more expensive, and often more difficult to access than their conventional counterparts.

For patients that are restricted in their ability to use organic foods in their diet, the best solution may be to recommend that they avoid foods in the dirty dozen list, as these have the highest concentration of pesticides and dangerous substances. An increased focus on organic nutrition may also be more valuable to vulnerable groups, such as young children, pregnant women, and the elderly.

Individuals who are limited in their ability to access organic foods or replace conventional foods with all-organic options can consider supplementation. As mentioned above, supplementation with the right highly nutritious substances can build upon the existing benefits of traditional fruits and vegetables. Additionally, with medicinal mushroom supplements like the Reishi plant, it’s possible to fight back against the inflammation that conventional products can cause.

Major medicinal mushroom supplements like Agaricus Blazei and Cordyceps Sinensis also deliver further benefits in the form of immune system support. A stronger immune system will be particularly beneficial to those unable to unlock the full benefits of organic nutrition.

Inflammatory diseases like Ankylosing Spondylitis Iritis represent one of the biggest challenges for medical professionals. Finding the source of chronic inflammation, and delivering treatment which minimises the problem without causing further side-effects requires careful planning.

Ankylosing Spondylitis Iritis is a component of Ankylosing Spondylitis, a chronic inflammatory condition responsible for stiffness, pain, and swelling. Though it’s more common for this condition to affect the hips, and spine, it can also influence all environments where ligaments and tendons intercede with bones.

Advanced Ankylosing Spondylitis (AS) can progress to influence spinal development, and can affect sensitive areas of the body, including the eyes. Approximately 40% of patients diagnosed with AS also experience eye inflammation.

The Challenges of Ankylosing Spondylitis Iritis

In most conditions of AS affecting the eyes, chronic uveitis is common, affecting the iris in multiple locations. Patients may experience symptoms one eye at a time, sometimes accompanied by other acute anterior uveitis symptoms, such as back pain, and swelling.

A significant risk of Acute Ankylosing Spondylitis Iritis is how quickly the condition can develop. Patients often notice symptoms appearing rapidly, and developing within a short space of time, usually between a few days or weeks.

Symptoms range from inflammation of the eye, to eye pain, clouded vision, light sensitivity, and decreased vision. Some patients also experience dark spots in their vision. A full fundoscopic exam or ophthalmoscopy can assist in detecting the extent of the inflammation.

Further tests for ocular pressure, or a slit lamp exam may further reveal additional pressure on the eye. Once a thorough diagnosis is established, the first line of treatment is often corticosteroids to reduce inflammation and side-effects. Immunosuppressants may allow for steroid tapering for those dependent on corticosteroids already.

Why Holistic Ankylosing Spondylitis Iritis Treatments?

Corticosteroid treatments are not 100% successful when addressing Ankylosing Spondylitis Iritis. High levels of dependence on steroids has reduced the efficacy of these treatment routes, requiring doctors to use higher doses, and immunosuppressant.

Research into steroids demonstrates numerous adverse side effects, including damage to the GI tract, gastric ulcer formation, and issues with the gut microbiota which may influence overall immunomodulation and response.

Overexposure to corticosteroids can further drive outcomes like impaired healing, hair thinning, and facial erythema. When corticosteroids aren’t successful, procedures may be required to remove vitreous within the eye and reduce pressure. Surgery to implant a device for releasing corticosteroid medication is also a possibility for AS treatment.

Unfortunately, these extreme treatment conditions can come with various side effects that harm the overall wellbeing over the patient.

A holistic treatment to Ankylosing Spondylitis Iritis would provide patients with an opportunity to rectify inflammation problems through positive lifestyle changes before surgery is necessary.

Natural Treatment Options

Physical therapy, hot and cold therapy, as well as lifestyle changes have all been deemed successful treatment methods for Ankylosing Spondylitis Iritis in some cases. Anti-inflammatory diets that remove dangerous substances from the daily routine reduces the risk of flare-ups.

Since no satisfactory pharmaceutical treatment appears to be available for the long-term treatment of AS, holistic approaches are gaining popularity, with a focus on reducing inflammation naturally, before turning to surgical answers.

Mycomedicine, or the use of medicinal mushrooms, offers a powerful solution for inflammation. Mushrooms have been extensively used throughout the years for their therapeutic effects and impact on inflammation. Mushrooms are rich in polysaccharides, indolic and phenolic compounds, which reduce inflammation on a deeper level. The metabolites from mushrooms also contain anti-cancer, antioxidant, and anti-inflammatory properties.

Reishi mushroom supplements, for instance, are proven to improve immune system performance, and promote healing in various parts of the body. Reishi can successfully reduce inflammation and encourage better sleep for healing.

Furthermore, because Reishi mushrooms contain beta glucan adaptogens, they’re capable of adapting rapidly to the unique needs of each patient when given in the correct combination and dose. Combined with its natural anti-inflammatory activity, Reishi’s unique benefits can help to overcome Ankylosing Spondylitis Iritis.

Since cooking mushrooms has the potential to reduce their inflammatory capabilities, extracts are the best treatment route. Mushrooms for inflammation are best given in extract form, where they can be reduced to their most powerful form, without any additional substances or calories.

 

The Mild Cognitive Impairment NHS recognised condition is a common neurological issue defining diminished cognitive abilities in a patient. In the UK, experts estimate that between 5 and 20% of all people over the age of 65 have MCI (Mild Cognitive Impairment).

Mild cognitive impairment symptoms may remain stable for a number of years, before gradually progressing to more severe levels. The symptoms of this condition include poor memory recollection, a change in problem solving skills, or issues with concentration, language, attention, visual ability, and thought processing.

Treating Mild Cognitive Impairment NHS

Mild Cognitive Impairment is more than just basic forgetfulness, but the symptoms are not yet significant enough to be classified as dementia. However, the NHS and other medical groups do recognise MCI as a potential warning sign of dementia and other cognitive ailments.

When identifying mild cognitive impairment, NHS professionals will examine the full extent of the issue, using blood tests and other means to determine whether the reason for your cognitive status may be linked to an underlying problem. MCI is diagnosed based on mental performance tests like the Mini-Mental State Examination (MMSE).

Treatment options include addressing the reversible causes of MCI. For instance, benzodiazepines can assist with treating anxiety, sleep disturbances and sleep issues, which all influence cognitive performance while anticholinergics affect the flow of chemicals in the nervous system. Unfortunately, many of these medications have negative side effects. What’s more, because they only treat the symptom, not the underlying issue, the condition may recur once the medication is stopped.

Holistic natural approaches are often considered the safer treatment route. Intellectual stimulation is proven to reduce cognitive decline and memory training can improve the storage of long-term memories. Medicinal mushrooms are also emerging as a powerful and clinically proven solution for MCI conditions.

Medicinal Mushrooms Support Cognitive Function

On a base level, medicinal mushrooms contain a number of valuable nutrients capable of supporting mental function. GABA, or Gamma-Aminobutyric Acid is effective at reducing stress levels and improving neural performance, while reducing the risk of insomnia. GABA supplementation can significantly improve cognitive performance in tasks like temporary visual attention.

Ergothioneine supplementation can help to prevent the risk of mild cognitive impairment, as cognitive issues often appear when levels of this substance begin to decrease naturally with age. Terpenoids in medicinal mushrooms also contribute to myelin regeneration, nerve growth factor synthesis, anti-inflammatory activities, and antioxidant performance.

Studies have begun to show that extracts and compounds from medicinal mushrooms can significantly improve cognitive performance and reduce the risk of cognitive decline. Some specific types of medicinal mushrooms are particularly valuable.

A project called Neurofood developed by Foltra foundation and HdT, a Spanish biotech specialised in mushroom nutraceuticals,  examined the abilities of mushrooms to improve neurocognitive functions. Researchers found that the use of medicinal mushroom extracts could significantly improve memory recall, attention and processing speed. Participants also demonstrated enhanced visuospatial skills following the use of medicinal mushrooms.

Which Mushrooms Support Brain Health?

For instance, the Hericium erinaceus (Lion’s mane) mushroom proved its impact on cognitive impairment in a study wherein patients ingested the mushroom extract for 16 weeks. At the end of the 16 weeks, cognitive function improved. Even four weeks after treatment was stopped, the cognition of the patients remained improved according to the Hasegawa Dementia Scale – Revised. [Mori et al., 2009].

The benefit of H.erinaceus comes from its ability to regenerate myelin and new synapses thanks to erinacines and hericenones acting as nerve growth-factor enhancing agents. [Kawagishi and Zhuang, 2008; Mori et al., 2008; Ma et al., 2010]. This medicinal mushroom improves neuronal stability and improves normal brain cell development.

Double-blind studies have further proven that patients given the Hericium erinaceus mushroom achieved much higher scales on the Hasegawa Dementia scale compared to those treated with a placebo.

Research into the Polysaccharides in Ganoderma lucidum also demonstrates that this mushroom can significantly improve cognitive function. The administration of G.lucidum extract in this study promoted the proliferation of the neural progenitor cell for enhanced neurogenesis.

Reishi, or Ganoderma lucidum mushroom is also known as an effective anti-aging mushroom. High levels of antioxidants in this mushroom significantly improve cognitive function by reducing cell aging and tissue damage which may impair mental abilities.

Using Medicinal Mushrooms for Cognitive Strength

Increasingly, medicinal mushrooms are proving their abilities to regenerate damaged parts of the brain and improve neural pathways. Backed by science, these mushrooms demonstrate significant value for those suffering from cognitive issues like Mild Cognitive Impairment.

As a safe substance without any potential side effects, medicinal mushrooms can also work in conjunction with other treatments. However, the right quality of the mushroom extract is necessary. High potency standardized extracts grown organically and no artificial fillers deliver the best results.

 

Chemotherapy is proven to be a highly effective treatment for various forms of cancer. However, as an aggressive form of treatment, chemotherapy can also have side effects of its own, from hair loss and nausea to depression and fatigue. Managing the side effects of chemotherapy is an important part of a holistic approach to ensuring quality of life for the cancer patient.

The benefits of medicinal mushrooms and their unique bioactive compounds are rapidly gaining attention as a solution to various mental and physical ailments. Research into the concept of “mycomedicine”, which leverages the medicinal benefits of extracts within these mushrooms proves the efficacy of natural treatments for various conditions, including chemotherapy side effects.

Studies demonstrate the beneficial impact of medicinal mushroom extracts used either synergistically with radiation and chemotherapy, or as single agents.

Reducing Chemotherapy Side Effects with Medicinal Mushrooms

The concept of Mycomedicine and the use of medicinal mushrooms in a patient treatment dates back to almost the beginning of healthcare practice. Compounds from the unique components of medicinal mushrooms are already approved as a safe, clinical treatment within China and Japan.

Many clinical trials in cancer patients, included for example in a prestigious Cochrane review,   demonstrate that medicinal mushrooms like Ganoderma lucidum (Reishi) are well tolerated when used alongside other cancer treatments. This medicinal mushroom is particularly effective at stimulating the immune system, and supporting the recovery of the body, through beta-glucans, triterpenes, ergosterol and other key bioactive molecules.

According to studies, the administration of Ganoderma lucidum extract alongside radiation or chemotherapy can improve tumour response by up to 1.27 times, while improving patient immune response. The bioactive compounds of these mushrooms such as beta-D-glucans or ganoderic acids also assist with improving quality of life and immune function

Besides Reishi, the use of Maitake, or Grifola frondosa, as an adjuvant to chemotherapy has been shown to reduce the side effects associated with cancer treatment like leukopenia, pain, vomiting or need of erythropheresis having also e a synergistic effect on tumour regression in several types of cancer.

It is also important to highlight that for more than 40 years, Polysaccharide-K (PSK) products derived from another medicinal mushroom called Coriolus versicolor, have demonstrated non-interaction with chemotherapy drugs, ensuring safe combined treatments. At the same time, these substances lead to a better overall quality of treatment, and better outcomes than chemotherapy alone.

As adaptogens, medicinal mushroom extracts can safely complement oncological treatments (chemo, radiotherapy, immunotherapy) by preserving the performance of the immune system, while counteracting side-effects like nausea, anaemia, and low resistance to viral infection. The anti-cancer compounds in medicinal mushrooms play a crucial role as mitotic kinase inhibitors, reactive oxygen species inducers, topoisomerase inhibitors, and angiogenesis inhibitors, leading to apoptosis.

The Impact of Medicinal Mushrooms on Cancer Treatment

The bioactive compounds in medicinal mushrooms have the capacity to improve the performance of the standard treatments used for cancer patients, while simultaneously improving quality of life by reducing common conditions like nausea and even lost bone density.

In particular, these bioactive molecules are beta-glucans, other polysaccharides, terpenoids like triterpenes, proteoglycans, vitamins and minerals among others, which contribute to an immunomodulatory healthy state that benefits cancer treatment.  Bioactive molecules in mushrooms are also described in literature as antitumour, antiangiogenic, antimetastatic and cytotoxic for cancer cells. Studies further reveal some anticancer compounds from mushrooms in combination with commercial anti-cancer drugs can even improve the treatment of drug-resistant cancers.

Medicinal mushroom supplemented patients can also benefit from significant reductions to chemotherapy side-effects, improving quality of life during treatments. The administration of medicinal mushroom extracts can effectively counteract issues like loss of appetite, emotional instability, alopecia, and general weakness.

The administration of Cordyceps sinensis as an adjuvant treatment with conventional chemotherapy and similar treatments also proves to be promising for the reduction of serum creatinine. This extract is effective at increasing creatinine clearance, reducing proteinuria, and alleviating complexities associated with chronic nephropathy.

Cordyceps sinensis is also proven to be an effective treatment for the management of fatigue and energy distribution in the human body. As general weakness, muscle aches, and fatigue are common problems associated with chemotherapy and cancer treatments; this substance could be a valuable supplemental treatment to enhance quality of life.

Used correctly, the anti-cancer compounds within medicinal mushrooms can provide additional relief from side effects commonly associated with chemotherapy and other cancer treatments, by helping to rebalance homeostasis, supporting the immune system, and managing pain responses.

Medical Mushrooms to Improve Chemotherapy

While chemotherapy is still regarded as the best treatment for cancer, it has various limitations when it comes to preserving quality of life for patients. Medicinal mushrooms are rapidly proving to be some of the best counteractive measures for those suffering from chemotherapy side effects, ranging from alopecia, to poor immunity and fatigue.

Safe for use synergistically with traditional treatments, medicinal mushrooms provide a safe and effective solution for integrative oncology. However, professionals must commit to seeking high-quality products to achieve the most effective outcomes. The best results from medicinal mushrooms are obtained from the synergy of powerful organic extracts with standardized bioactive molecules.

Quality medicinal mushroom treatments will become more common in the future of cancer management as studies continue to prove the safety and potential of this therapy.